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2020 ; 1221
(ä): 3-59
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Forty Years of Basic and Translational Heparanase Research
#MMPMID32274705
Vlodavsky I
; Ilan N
; Sanderson RD
Adv Exp Med Biol
2020[]; 1221
(ä): 3-59
PMID32274705
show ga
This review summarizes key developments in the heparanase field obtained 20 years
prior to cloning of the HPSE gene and nearly 20 years after its cloning. Of the
numerous publications and review articles focusing on heparanase, we have
selected those that best reflect the progression in the field as well as those we
regard important accomplishments with preference to studies performed by
scientists and groups that contributed to this book. Apart from a general
'introduction' and 'concluding remarks', the abstracts of these studies are
presented essentially as published along the years. We apologize for not being
objective and not being able to include some of the most relevant abstracts and
references, due to space limitation. Heparanase research can be divided into two
eras. The first, initiated around 1975, dealt with identifying the enzyme,
establishing the relevant assay systems and investigating its biological
activities and significance in cancer and other pathologies. Studies performed
during the first area are briefly introduced in a layman style followed by the
relevant abstracts presented chronologically, essentially as appears in PubMed.
The second era started in 1999 when the heparanase gene was independently cloned
by 4 research groups [1-4]. As expected, cloning of the heparanase gene boosted
heparanase research by virtue of the readily available recombinant enzyme,
molecular probes, and anti-heparanase antibodies. Studies performed during the
second area are briefly introduced followed by selected abstracts of key
findings, arranged according to specific topics.