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2017 ; 8
(4
): 245-250
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Formin-mediated epigenetic maintenance of centromere identity
#MMPMID27449713
Liu C
; Mao Y
Small GTPases
2017[Oct]; 8
(4
): 245-250
PMID27449713
show ga
Accurate chromosome segregation in mammalian cells is guided by the centromere, a
specialized chromosome region defined by the histone H3 variant centromere
protein A (CENP-A). It is not well understood how cells maintain CENP-A levels at
centromeres while continuously going through genome replications and cell
divisions. A MgcRacGAP-dependent small GTPase molecular switch has been shown as
essential for centromeric CENP-A maintenance. By using quantitative imaging,
pulse-chase and live cell analysis, a recent work has suggested that the
diaphanous formin mDia2, a well-established small GTPase effector, functions
downstream of this small GTPase pathway to maintain CENP-A levels at centromeres.
A constitutively active mDia2 construct is able to rescue the CENP-A loading
defect caused by MgcRacGAP depletion. This study has uncovered an unsuspected
role of the cytoskeleton protein mDia2 as an effector of the MgcRacGAP-dependent
small GTPase signaling inside the nucleus to participate in the epigenetic
regulation of centromere maintenance during cell cycle.
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