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Formation of metabolic water by aerobic glucose oxidation
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Fluids Barriers CNS
2025[Oct]; 22
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PMID41131570
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A recent paper suggests that the water originating from the ATP production
coupled to aerobic glucose oxidation causes more than a 6 fold increase in the
production of metabolic water, compared with the standard textbook description of
the oxidation process. However, the authors seem to have forgotten that the
simultaneous processes of ATP utilization takes up the same amount of water,
which was liberated during the ATP synthesis. Thus, at steady state, there is no
net increase in the production of metabolic water.