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2015 ; 15
(3
): e411-4
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Follicular Dendritic Cell Sarcoma: Cytogenetics and pathological findings
#MMPMID26355964
Udayakumar AM
; Al-Bahri M
; Burney IA
; Al-Haddabi I
Sultan Qaboos Univ Med J
2015[Aug]; 15
(3
): e411-4
PMID26355964
show ga
Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm with a non-specific
and insidious presentation further complicated by the difficult diagnostic and
therapeutic assessment. It has a low to intermediate risk of recurrence and
metastasis. Unlike other soft tissue sarcomas or histiocytic and dendritic cell
neoplasms, cytogenetic studies are very limited in FDCS cases. Although no
specific chromosomal marker has yet been established, complex aberrations and
different ploidy types have been documented. We report the case of a 39-year-old
woman with FDCS who presented to the Sultan Qaboos University Hospital in Muscat,
Oman, in February 2013. Ultrastructural, immunophenotypical and histological
findings are reported. In addition, karyotypic findings showed deletions of the
chromosomes 1p, 3q, 6q, 7q, 8q and 11q. To the best of the authors' knowledge,
these have not been reported previously in this tumour. Techniques such as
spectral karyotyping may help to better characterise chromosomal abnormalities in
this type of tumour.