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2016 ; 343
(1
): 14-20
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Focal adhesions, stress fibers and mechanical tension
#MMPMID26519907
Burridge K
; Guilluy C
Exp Cell Res
2016[Apr]; 343
(1
): 14-20
PMID26519907
show ga
Stress fibers and focal adhesions are complex protein arrays that produce,
transmit and sense mechanical tension. Evidence accumulated over many years led
to the conclusion that mechanical tension generated within stress fibers
contributes to the assembly of both stress fibers themselves and their associated
focal adhesions. However, several lines of evidence have recently been presented
against this model. Here we discuss the evidence for and against the role of
mechanical tension in driving the assembly of these structures. We also consider
how their assembly is influenced by the rigidity of the substratum to which cells
are adhering. Finally, we discuss the recently identified connections between
stress fibers and the nucleus, and the roles that these may play, both in cell
migration and regulating nuclear function.