Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25064553
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Adv+Drug+Deliv+Rev
2014 ; 76
(ä): 21-38
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Fluorescent imaging of cancerous tissues for targeted surgery
#MMPMID25064553
Bu L
; Shen B
; Cheng Z
Adv Drug Deliv Rev
2014[Sep]; 76
(ä): 21-38
PMID25064553
show ga
To maximize tumor excision and minimize collateral damage are the primary goals
of cancer surgery. Emerging molecular imaging techniques have made "image-guided
surgery" developed into "molecular imaging-guided surgery", which is termed as
"targeted surgery" in this review. Consequently, the precision of surgery can be
advanced from tissue-scale to molecule-scale, enabling "targeted surgery" to be a
component of "targeted therapy". Evidence from numerous experimental and clinical
studies has demonstrated significant benefits of fluorescent imaging in targeted
surgery with preoperative molecular diagnostic screening. Fluorescent imaging can
help to improve intraoperative staging and enable more radical cytoreduction,
detect obscure tumor lesions in special organs, highlight tumor margins, better
map lymph node metastases, and identify important normal structures
intraoperatively. Though limited tissue penetration of fluorescent imaging and
tumor heterogeneity are two major hurdles for current targeted surgery,
multimodality imaging and multiplex imaging may provide potential solutions to
overcome these issues, respectively. Moreover, though many fluorescent imaging
techniques and probes have been investigated, targeted surgery remains at a
proof-of-principle stage. The impact of fluorescent imaging on cancer surgery
will likely be realized through persistent interdisciplinary amalgamation of
research in diverse fields.