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2015 ; 4
(4
): 860-80
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Fish Peroxiredoxins and Their Role in Immunity
#MMPMID26633533
Valero Y
; Martínez-Morcillo FJ
; Esteban MÁ
; Chaves-Pozo E
; Cuesta A
Biology (Basel)
2015[Nov]; 4
(4
): 860-80
PMID26633533
show ga
Peroxiredoxins (Prxs) are a family of antioxidant enzymes that protect cells from
oxidative damage. In addition, Prxs may act as modulators of inflammation,
protect against cell death and tumour progression, and facilitate tissue repair
after damage. The most studied roles of Prx1 and Prx2 are immunological. Here we
present a review on the effects of some immunostimulant treatments and bacterial,
viral, or parasitic infections on the expression of fish Prxs at the gene and/or
protein level, and point to their important role in immunity. The Prxs show
antioxidant activity as well as a protective effect against infection. Some
preliminary data are presented about the role of fish Prx1 and Prx2 in virus
resistance although further studies are needed before the role of fish Prx in
immunity can be definitively defined.