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10.1681/ASN.2016010061

http://scihub22266oqcxt.onion/10.1681/ASN.2016010061
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suck abstract from ncbi


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pmid27147425
      J+Am+Soc+Nephrol 2016 ; 27 (7 ): 1911-5
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  • Filgrastim-Induced Crescentic Transformation of Recurrent IgG2? GN #MMPMID27147425
  • Batal I ; Markowitz GS ; Wong W ; Avasare R ; Mapara MY ; Appel GB ; D'Agati VD
  • J Am Soc Nephrol 2016[Jul]; 27 (7 ): 1911-5 PMID27147425 show ga
  • Proliferative GN with monoclonal IgG deposits is an increasingly recognized form of GN, but its relation to hematologic malignancy remains poorly understood. Filgrastim, an analog for granulocyte colony-stimulating factor produced by recombinant DNA technology, is frequently used to stimulate bone marrow release of hematopoietic progenitor cells in preparation for stem cell transplant. We report an exceptional case of proliferative GN with monoclonal IgG2? deposits in a young man whose disease progressed slowly to CKD, which was followed by a preemptive kidney transplant. The patient developed recurrent GN in the allograft and clinically detectable plasma cell neoplasm 9 years after the first renal manifestations. Contemporaneous with filgrastim administration for stem cell mobilization, the patient's slowly progressive GN underwent severe crescentic transformation, leading to rapidly progressive and irreversible allograft failure. This report explores the spectrum of GN with monoclonal IgG deposits and the pathophysiologic role of granulocyte colony-stimulating factor in exacerbation of preexisting GN.
  • |*Immunoglobulin G [MESH]
  • |*Kidney Transplantation [MESH]
  • |Adult [MESH]
  • |Filgrastim/*adverse effects [MESH]
  • |Glomerulonephritis, Membranoproliferative/*chemically induced/*pathology [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Postoperative Complications/*chemically induced/*pathology [MESH]


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