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2016 ; 128
(21-22
): 796-801
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Fever of unknown origin (FUO) revised
#MMPMID27670857
Unger M
; Karanikas G
; Kerschbaumer A
; Winkler S
; Aletaha D
Wien Klin Wochenschr
2016[Nov]; 128
(21-22
): 796-801
PMID27670857
show ga
Fever of unknown origin (FUO) was originally characterised in 1961 by Petersdorf
and Beeson as a disease condition of temperature exceeding 38.3 °C on at least
three occasions over a period of at least three weeks, with no diagnosis made
despite one week of inpatient investigation. However, since underlying diseases
are often reported for classical FUO, these presentations may not be considered
to be of "unknown origin". Rather, the aetiology of prolonged fever may resolve,
or not resolve. The definition of fever with unresolved cause (true FUO) is
difficult, as it is a moving target, given the constant advancement of imaging
and biomarker analysis. Therefore, the prevalence of fever with unresolved cause
(FUO) is unknown.In this review, we report such a case of prolonged fever, which
initially has presented as classical FUO, and discuss current literature.
Furthermore, we will give an outlook, how a prospective study on FUO will allow
to solve outstanding issues like the utility of different diagnostic
investigations, and the types and prevalence of various underlying diseases.
|Diagnosis, Differential
[MESH]
|Evidence-Based Medicine
[MESH]
|Fever of Unknown Origin/*diagnosis/etiology/*therapy
[MESH]
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