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10.1007/s10689-014-9714-7 http://scihub22266oqcxt.onion/10.1007/s10689-014-9714-7 C4357528!4357528 !24677027     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24677027 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Fam+Cancer 2014 ; 13 (3 ): 369-74 Nephropedia Template TP {{tp|p=24677027 |t=2014. Fertility and apparent genetic anticipation in Lynch syndrome |pdf=|usr=}}{{24677027 }} gab.com Text Fertility and apparent genetic anticipation in Lynch syndrome JO: Fam Cancer http://www.kidney.de/pget.php?&tw=1&pmid=24677027 #FOAvip Genetic anticipation is the phenomenon in which age of onset of an inherited disorder decreases in successive generations. Inconsistent evidence suggests that this occurs in Lynch syndrome. A possible cause for apparent anticipation is fecundity bias, which occurs if the disease adversely affects fertility. The purpose of this study was to determine the effect of age of diagnosis of colorectal cancer (CRC) on lifetime fertility in Lynch syndrome, and whether this can falsely create the appearance of genetic anticipation. A computer model simulated age of diagnosis of CRC in hypothetical Lynch syndrome carriers and their offspring. The model assumed similar age distribution of CRC across generations (i.e. that there was no true anticipation). Age distribution of CRC diagnosis, and lifetime fertility rates (grouped by age of diagnosis of CRC) were determined from the Australasian Colorectal Cancer Family Registry (ACCFR). Apparent anticipation was calculated by comparing ages of diagnosis of CRC in affected parent-child pairs. A total of 1,088 patients with CRC were identified from the ACCFR. Total lifetime (cohort) fertility was related to age of diagnosis of CRC (correlation coefficient 0.13, P = 0.0001). In the simulation, apparent anticipation was 1.8 ± 0.54 years (P = 0.0044). Observed apparent anticipation in the ACCFR cohort was 4.8 ± 1.73 years (P = 0.0064). There was no difference in apparent anticipation between the simulate d and observed parent-child pairs (P = 0.89). The appearance of genetic anticipation in Lynch syndrome can be falsely created due to changes in fertility. Twit Text FOAVip Fertility and apparent genetic anticipation in Lynch syndrome ????Fam Cancer http://www.kidney.de/pget.php?&tw=1&pmid=24677027 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24677027 #FOAvip English Wikipedia <ref>{{Cite pmid|24677027 }}</ref> Fertility and apparent genetic anticipation in Lynch syndrome #MMPMID24677027 Stupart D ; Win AK ; Jenkins M ; Winship IM ; Goldberg P ; Ramesar R Fam Cancer 2014[Sep]; 13 (3 ): 369-74 PMID24677027 show ga Genetic anticipation is the phenomenon in which age of onset of an inherited disorder decreases in successive generations. Inconsistent evidence suggests that this occurs in Lynch syndrome. A possible cause for apparent anticipation is fecundity bias, which occurs if the disease adversely affects fertility. The purpose of this study was to determine the effect of age of diagnosis of colorectal cancer (CRC) on lifetime fertility in Lynch syndrome, and whether this can falsely create the appearance of genetic anticipation. A computer model simulated age of diagnosis of CRC in hypothetical Lynch syndrome carriers and their offspring. The model assumed similar age distribution of CRC across generations (i.e. that there was no true anticipation). Age distribution of CRC diagnosis, and lifetime fertility rates (grouped by age of diagnosis of CRC) were determined from the Australasian Colorectal Cancer Family Registry (ACCFR). Apparent anticipation was calculated by comparing ages of diagnosis of CRC in affected parent-child pairs. A total of 1,088 patients with CRC were identified from the ACCFR. Total lifetime (cohort) fertility was related to age of diagnosis of CRC (correlation coefficient 0.13, P = 0.0001). In the simulation, apparent anticipation was 1.8 ± 0.54 years (P = 0.0044). Observed apparent anticipation in the ACCFR cohort was 4.8 ± 1.73 years (P = 0.0064). There was no difference in apparent anticipation between the simulate d and observed parent-child pairs (P = 0.89). The appearance of genetic anticipation in Lynch syndrome can be falsely created due to changes in fertility. |*Age of Onset [MESH] |*Anticipation, Genetic [MESH] |*Fertility [MESH] |Adult [MESH] |Colorectal Neoplasms, Hereditary Nonpolyposis/*epidemiology/*genetics [MESH] |Computer Simulation [MESH] |Female [MESH] |Humans [MESH] |Male [MESH]Fertility and apparent genetic anticipation in Lynch syndrome (epmc).pdf DeepDyve Pubget Overpricing