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2015 ; 1853
(6
): 1284-93
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Fe-S proteins that regulate gene expression
#MMPMID25450978
Mettert EL
; Kiley PJ
Biochim Biophys Acta
2015[Jun]; 1853
(6
): 1284-93
PMID25450978
show ga
Iron-sulfur (Fe-S) cluster containing proteins that regulate gene expression are
present in most organisms. The innate chemistry of their Fe-S cofactors makes
these regulatory proteins ideal for sensing environmental signals, such as gases
(e.g. O2 and NO), levels of Fe and Fe-S clusters, reactive oxygen species, and
redox cycling compounds, to subsequently mediate an adaptive response. Here we
review the recent findings that have provided invaluable insight into the
mechanism and function of these highly significant Fe-S regulatory proteins. This
article is part of a Special Issue entitled: Fe/S proteins: Analysis, structure,
function, biogenesis and diseases.