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2015 ; 2
(3
): e995041
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Fbw7 and Usp28 - enemies and allies
#MMPMID27308481
Taranets L
; Zhu J
; Xu W
; Popov N
Mol Cell Oncol
2015[Jul]; 2
(3
): e995041
PMID27308481
show ga
The Usp28 deubiquitinase antagonizes Fbw7-mediated turnover of multiple
oncoproteins, including Myc, Jun, and Notch, and promotes tumorigenesis in the
intestine. Our recent study reveals that Usp28 also counteracts autocatalytic
ubiquitination of Fbw7, suggesting a complex role for Usp28 in the regulation of
Fbw7 activity and tumor development.