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10.1016/j.cell.2016.04.006 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.04.006 C4881391!4881391 !27133164     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27133164 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell 2016 ; 165 (4 ): 867-81 Nephropedia Template TP {{tp|p=27133164 |t=2016. Fanconi Anemia Proteins Function in Mitophagy and Immunity |pdf=|usr=}}{{27133164 }} gab.com Text Fanconi Anemia Proteins Function in Mitophagy and Immunity JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27133164 #FOAvip Fanconi anemia (FA) pathway genes are important tumor suppressors whose best-characterized function is repair of damaged nuclear DNA. Here, we describe an essential role for FA genes in two forms of selective autophagy. Genetic deletion of Fancc blocks the autophagic clearance of viruses (virophagy) and increases susceptibility to lethal viral encephalitis. Fanconi anemia complementation group C (FANCC) protein interacts with Parkin, is required in vitro and in vivo for clearance of damaged mitochondria, and decreases mitochondrial reactive oxygen species (ROS) production and inflammasome activation. The mitophagy function of FANCC is genetically distinct from its role in genomic DNA damage repair. Moreover, additional genes in the FA pathway, including FANCA, FANCF, FANCL, FANCD2, BRCA1, and BRCA2, are required for mitophagy. Thus, members of the FA pathway represent a previously undescribed class of selective autophagy genes that function in immunity and organellar homeostasis. These findings have implications for understanding the pathogenesis of FA and cancers associated with mutations in FA genes. Twit Text FOAVip Fanconi Anemia Proteins Function in Mitophagy and Immunity ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27133164 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27133164 #FOAvip English Wikipedia <ref>{{Cite pmid|27133164 }}</ref> Fanconi Anemia Proteins Function in Mitophagy and Immunity #MMPMID27133164 Sumpter R Jr ; Sirasanagandla S ; Fernández ÁF ; Wei Y ; Dong X ; Franco L ; Zou Z ; Marchal C ; Lee MY ; Clapp DW ; Hanenberg H ; Levine B Cell 2016[May]; 165 (4 ): 867-81 PMID27133164 show ga Fanconi anemia (FA) pathway genes are important tumor suppressors whose best-characterized function is repair of damaged nuclear DNA. Here, we describe an essential role for FA genes in two forms of selective autophagy. Genetic deletion of Fancc blocks the autophagic clearance of viruses (virophagy) and increases susceptibility to lethal viral encephalitis. Fanconi anemia complementation group C (FANCC) protein interacts with Parkin, is required in vitro and in vivo for clearance of damaged mitochondria, and decreases mitochondrial reactive oxygen species (ROS) production and inflammasome activation. The mitophagy function of FANCC is genetically distinct from its role in genomic DNA damage repair. Moreover, additional genes in the FA pathway, including FANCA, FANCF, FANCL, FANCD2, BRCA1, and BRCA2, are required for mitophagy. Thus, members of the FA pathway represent a previously undescribed class of selective autophagy genes that function in immunity and organellar homeostasis. These findings have implications for understanding the pathogenesis of FA and cancers associated with mutations in FA genes. |Animals [MESH] |Autophagy [MESH] |Embryo, Mammalian/cytology [MESH] |Fanconi Anemia Complementation Group C Protein/genetics/*metabolism [MESH] |Fanconi Anemia Complementation Group Proteins/metabolism [MESH] |Fibroblasts/metabolism [MESH] |HeLa Cells [MESH] |Herpesvirus 1, Human/metabolism [MESH] |Humans [MESH] |Inflammasomes/metabolism [MESH] |Mice [MESH] |Mitophagy [MESH] |Reactive Oxygen Species/metabolism [MESH]Fanconi Anemia Proteins Function in Mitophagy and Immunity (epmc).pdf DeepDyve Pubget Overpricing