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2015 ; 2015
(ä): 690692
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Factors influencing the eicosanoids synthesis in vivo
#MMPMID25861641
Szefel J
; Kruszewski WJ
; Sobczak E
Biomed Res Int
2015[]; 2015
(ä): 690692
PMID25861641
show ga
External factors activate a sequence of reactions involving the reception,
transduction, and transmission of signals to effector cells. There are two main
phases of the body's reaction to harmful factors: the first aims to neutralize
the harmful factor, while in the second the inflammatory process is reduced in
size and resolved. Secondary messengers such as eicosanoids are active in both
phases. The discovery of lipoxins and epi-lipoxins demonstrated that not all
arachidonic acid (AA) derivatives have proinflammatory activity. It was also
revealed that metabolites of eicosapentaenoic acid (EPA) and docosahexaenoic acid
(DHA) such as resolvins, protectins, and maresins also take part in the
resolution of inflammation. Knowledge of the above properties has stimulated
several clinical trials on the influence of EPA and DHA supplementation on
various diseases. However, the equivocal results of those trials prevent the
formulation of guidelines on EPA and DHA supplementation. Prescription drugs are
among the substances with the strongest influence on the profile and quantity of
the synthesized eicosanoids. The lack of knowledge about their influence on the
conversion of EPA and DHA into eicosanoids may lead to erroneous conclusions from
clinical trials.
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