Facial and hand allotransplantation
#MMPMID24478387
Pomahac B
; Gobble RM
; Schneeberger S
Cold Spring Harb Perspect Med
2014[Mar]; 4
(3
): ? PMID24478387
show ga
Vascularized composite allotransplantation (VCA) is a novel therapeutic option
for treatment of patients suffering from limb loss or severe facial
disfigurement. To date, 72 hand and 19 facial transplantations have been
performed worldwide. VCA in hand and facial transplantation is a complex
procedure requiring a multidisciplinary team approach and extensive surgical
planning. Despite good functional outcome, courses after hand and facial
transplantation have been complicated by skin rejection. Long-term
immunosuppression remains a necessity in VCA for allograft survival. To widen the
scope of these quality-of-life-improving procedures, minimization of
immunosuppression to limit risks and side effects is needed.
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