Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27066483
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Cell+Dev+Biol
2016 ; 4
(ä): 26
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
FXYD5: Na(+)/K(+)-ATPase Regulator in Health and Disease
#MMPMID27066483
Lubarski Gotliv I
Front Cell Dev Biol
2016[]; 4
(ä): 26
PMID27066483
show ga
FXYD5 (Dysadherin, RIC) is a single span type I membrane protein that plays
multiple roles in regulation of cellular functions. It is expressed in a variety
of epithelial tissues and acts as an auxiliary subunit of the Na(+)/K(+)-ATPase.
During the past decade, a correlation between enhanced expression of FXYD5 and
tumor progression has been established for various tumor types. In this review,
current knowledge on FXYD5 is discussed, including experimental data on the
functional effects of FXYD5 on the Na(+)/K(+)-ATPase. FXYD5 modulates cellular
junctions, influences chemokine production, and affects cell adhesion. The
accumulated data may provide a basis for understanding the molecular mechanisms
underlying FXYD5 mediated phenotypes.