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10.1038/nature22322 http://scihub22266oqcxt.onion/10.1038/nature22322 C5427179!5427179 !28467822     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28467822 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nature 2017 ; 545 (7653 ): 224-228 Nephropedia Template TP {{tp|p=28467822 |t=2017. FGF-dependent metabolic control of vascular development |pdf=|usr=}}{{28467822 }} gab.com Text FGF-dependent metabolic control of vascular development JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=28467822 #FOAvip Blood and lymphatic vasculatures are intimately involved in tissue oxygenation and fluid homeostasis maintenance. Assembly of these vascular networks involves sprouting, migration and proliferation of endothelial cells. Recent studies have suggested that changes in cellular metabolism are important to these processes. Although much is known about vascular endothelial growth factor (VEGF)-dependent regulation of vascular development and metabolism, little is understood about the role of fibroblast growth factors (FGFs) in this context. Here we identify FGF receptor (FGFR) signalling as a critical regulator of vascular development. This is achieved by FGF-dependent control of c-MYC (MYC) expression that, in turn, regulates expression of the glycolytic enzyme hexokinase 2 (HK2). A decrease in HK2 levels in the absence of FGF signalling inputs results in decreased glycolysis, leading to impaired endothelial cell proliferation and migration. Pan-endothelial- and lymphatic-specific Hk2 knockouts phenocopy blood and/or lymphatic vascular defects seen in Fgfr1/Fgfr3 double mutant mice, while HK2 overexpression partly rescues the defects caused by suppression of FGF signalling. Thus, FGF-dependent regulation of endothelial glycolysis is a pivotal process in developmental and adult vascular growth and development. Twit Text FOAVip FGF-dependent metabolic control of vascular development ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=28467822 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28467822 #FOAvip English Wikipedia <ref>{{Cite pmid|28467822 }}</ref> FGF-dependent metabolic control of vascular development #MMPMID28467822 Yu P ; Wilhelm K ; Dubrac A ; Tung JK ; Alves TC ; Fang JS ; Xie Y ; Zhu J ; Chen Z ; De Smet F ; Zhang J ; Jin SW ; Sun L ; Sun H ; Kibbey RG ; Hirschi KK ; Hay N ; Carmeliet P ; Chittenden TW ; Eichmann A ; Potente M ; Simons M Nature 2017[May]; 545 (7653 ): 224-228 PMID28467822 show ga Blood and lymphatic vasculatures are intimately involved in tissue oxygenation and fluid homeostasis maintenance. Assembly of these vascular networks involves sprouting, migration and proliferation of endothelial cells. Recent studies have suggested that changes in cellular metabolism are important to these processes. Although much is known about vascular endothelial growth factor (VEGF)-dependent regulation of vascular development and metabolism, little is understood about the role of fibroblast growth factors (FGFs) in this context. Here we identify FGF receptor (FGFR) signalling as a critical regulator of vascular development. This is achieved by FGF-dependent control of c-MYC (MYC) expression that, in turn, regulates expression of the glycolytic enzyme hexokinase 2 (HK2). A decrease in HK2 levels in the absence of FGF signalling inputs results in decreased glycolysis, leading to impaired endothelial cell proliferation and migration. Pan-endothelial- and lymphatic-specific Hk2 knockouts phenocopy blood and/or lymphatic vascular defects seen in Fgfr1/Fgfr3 double mutant mice, while HK2 overexpression partly rescues the defects caused by suppression of FGF signalling. Thus, FGF-dependent regulation of endothelial glycolysis is a pivotal process in developmental and adult vascular growth and development. |*Glycolysis [MESH] |*Neovascularization, Physiologic [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Endothelial Cells/*cytology/*metabolism [MESH] |Female [MESH] |Fibroblast Growth Factors/*metabolism [MESH] |Hexokinase/metabolism [MESH] |Lymphangiogenesis [MESH] |Lymphatic Vessels/cytology/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Proto-Oncogene Proteins c-myc/metabolism [MESH] |Receptor, Fibroblast Growth Factor, Type 1/deficiency/genetics/metabolism [MESH]FGF-dependent metabolic control of vascular development (epmc).pdf DeepDyve Pubget Overpricing