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10.1097/WCO.0000000000000437 http://scihub22266oqcxt.onion/10.1097/WCO.0000000000000437 C6051727!6051727 !28248698     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28248698 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28248698 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Neurol 2017 ; 30 (3 ): 263-271 Nephropedia Template TP {{tp|p=28248698 |t=2017. Extracranial origin of headache |pdf=|usr=}}{{28248698 }} gab.com Text Extracranial origin of headache JO: Curr Opin Neurol http://www.kidney.de/pget.php?&tw=1&pmid=28248698 #FOAvip PURPOSE OF REVIEW: To summarize recent clinical and preclinical studies on extracranial pathophysiologies in migraine. It challenges the opinion-based notion that the headache phase of migraine occurs without input from peripheral nociceptors or is caused solely by activation of intracranial nociceptors supplying dural and cerebral vasculature. RECENT FINDINGS: Data that support a scenario by which migraine can originate extracranially include the perception of imploding headache that hurts outside the cranium, the existence of a network of sensory fibers that bifurcate from parent axons of intracranial meningeal nociceptors and reach extracranial tissues such as periosteum and pericranial muscles by crossing the calvarial bones through the sutures, the discovery of proinflammatory genes that are upregulated and anti-inflammatory genes that are down regulated in extracranial tissue of chronic migraine patients, and evidence that administration of OnabotulinumtoxinA to peripheral tissues outside the calvaria reduces frequency of migraine headache. SUMMARY: These findings seeks to shift clinical practice from prophylactically treating chronic migraine solely with medications that reduce neuronal excitability to treating irritated nociceptors or affected tissues. The findings also seeks to shift current research from focusing solely on central nervous system alterations and activation of meningeal nociceptors as a prerequisite for studying migraine. Twit Text FOAVip Extracranial origin of headache ????Curr Opin Neurol http://www.kidney.de/pget.php?&tw=1&pmid=28248698 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28248698 #FOAvip English Wikipedia <ref>{{Cite pmid|28248698 }}</ref> Extracranial origin of headache #MMPMID28248698 Burstein R ; Blake P ; Schain A ; Perry C Curr Opin Neurol 2017[Jun]; 30 (3 ): 263-271 PMID28248698 show ga PURPOSE OF REVIEW: To summarize recent clinical and preclinical studies on extracranial pathophysiologies in migraine. It challenges the opinion-based notion that the headache phase of migraine occurs without input from peripheral nociceptors or is caused solely by activation of intracranial nociceptors supplying dural and cerebral vasculature. RECENT FINDINGS: Data that support a scenario by which migraine can originate extracranially include the perception of imploding headache that hurts outside the cranium, the existence of a network of sensory fibers that bifurcate from parent axons of intracranial meningeal nociceptors and reach extracranial tissues such as periosteum and pericranial muscles by crossing the calvarial bones through the sutures, the discovery of proinflammatory genes that are upregulated and anti-inflammatory genes that are down regulated in extracranial tissue of chronic migraine patients, and evidence that administration of OnabotulinumtoxinA to peripheral tissues outside the calvaria reduces frequency of migraine headache. SUMMARY: These findings seeks to shift clinical practice from prophylactically treating chronic migraine solely with medications that reduce neuronal excitability to treating irritated nociceptors or affected tissues. The findings also seeks to shift current research from focusing solely on central nervous system alterations and activation of meningeal nociceptors as a prerequisite for studying migraine. |Botulinum Toxins, Type A/therapeutic use [MESH] |Headache Disorders/*etiology/*physiopathology/prevention & control [MESH] |Humans [MESH] |Migraine Disorders/*etiology/*physiopathology/prevention & control [MESH]Extracranial origin of headache (epmc).pdf DeepDyve Pubget Overpricing