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2018 ; 7
(1
): 1438720
Nephropedia Template TP
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Extracellular vesicles: the growth as diagnostics and therapeutics; a survey
#MMPMID29511461
Roy S
; Hochberg FH
; Jones PS
J Extracell Vesicles
2018[]; 7
(1
): 1438720
PMID29511461
show ga
This article aims to document the growth in extracellular vesicle (EV) research.
Here, we report the growth in EV-related studies, patents, and grants as well as
emerging companies with major intent on exosomes. Four different databases were
utilized for electronic searches of published literature: two general databases -
Scopus/Elsevier and Web of Science (WoS), as well as two specialized US
government databases - the USA Patent and Trademark Office and National
Institutes of Health (NIH) of the Department of Health and Human Services. The
applied combination of key words was carefully chosen to cover the most commonly
used terms in titles of publications, patents and grants dealing with conceptual
areas of EVs. Within the time frame from 1 January 2000 to 31 December 2016,
limited to articles published in English, we identified output using search
strategies based upon Scopus/Elsevier and WoS, patent filings and NIH Federal
Reports of funded grants. Consistently, USA and UK universities are the most
frequent among the top 15 affiliations/organizations of the authors of the
identified records. There is clear evidence of upward streaming of EV-related
publications. By documenting the growth of the EV field, we hope to encourage a
roster of independent authorities skilled to provide peer review of manuscripts,
evaluation of grant applications, support of foundation initiatives and corporate
long-term planning. It is important to encourage EV research to further identify
biomarkers in diseases and allow for the development of adequate diagnostic tools
that could distinguish disease subpopulations and enable personalized treatment
of patients.