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2014 ; 20
(7
): 385-93
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Extracellular vesicles: emerging targets for cancer therapy
#MMPMID24703619
Vader P
; Breakefield XO
; Wood MJ
Trends Mol Med
2014[Jul]; 20
(7
): 385-93
PMID24703619
show ga
Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic
bodies, are released by almost all cell types, including tumour cells. Through
transfer of their molecular contents, EVs are capable of altering the function of
recipient cells. Increasing evidence suggests a key role for EV mediated
intercellular communication in a variety of cellular processes involved in tumour
development and progression, including immune suppression, angiogenesis, and
metastasis. Aspects of EV biogenesis or function are therefore increasingly being
considered as targets for anticancer therapy. Here, we summarise the current
knowledge on the contributions of EVs to cancer pathogenesis and discuss novel
therapeutic strategies to target EVs to prevent tumour growth and spread.