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10.1111/bph.13505 http://scihub22266oqcxt.onion/10.1111/bph.13505 C4919578!4919578 !27128025     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27128025 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27128025 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Br+J+Pharmacol 2016 ; 173 (14 ): 2182-94 Nephropedia Template TP {{tp|p=27128025 |t=2016. Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine |pdf=|usr=}}{{27128025 }} gab.com Text Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27128025 #FOAvip In this review, we focus on the secreted form of nicotinamide phosphoribosyltransferase (NAMPT); extracellular NAMPT (eNAMPT), also known as pre-B cell colony-enhancing factor or visfatin. Although intracellular NAMPT is a key enzyme in controlling NAD metabolism, eNAMPT has been reported to function as a cytokine, with many roles in physiology and pathology. Circulating eNAMPT has been associated with several metabolic and inflammatory disorders, including cancer. Because cytokines produced in the tumour micro-environment play an important role in cancer pathogenesis, in part by reprogramming cellular metabolism, future improvements in cancer immunotherapy will require a better understanding of the crosstalk between cytokine action and tumour biology. In this review, the knowledge of eNAMPT in cancer will be discussed, focusing on its immunometabolic function as a metabokine, its secretion, its mechanism of action and possible roles in the cancer micro-environment. Twit Text FOAVip Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27128025 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27128025 #FOAvip English Wikipedia <ref>{{Cite pmid|27128025 }}</ref> Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine #MMPMID27128025 Grolla AA ; Travelli C ; Genazzani AA ; Sethi JK Br J Pharmacol 2016[Jul]; 173 (14 ): 2182-94 PMID27128025 show ga In this review, we focus on the secreted form of nicotinamide phosphoribosyltransferase (NAMPT); extracellular NAMPT (eNAMPT), also known as pre-B cell colony-enhancing factor or visfatin. Although intracellular NAMPT is a key enzyme in controlling NAD metabolism, eNAMPT has been reported to function as a cytokine, with many roles in physiology and pathology. Circulating eNAMPT has been associated with several metabolic and inflammatory disorders, including cancer. Because cytokines produced in the tumour micro-environment play an important role in cancer pathogenesis, in part by reprogramming cellular metabolism, future improvements in cancer immunotherapy will require a better understanding of the crosstalk between cytokine action and tumour biology. In this review, the knowledge of eNAMPT in cancer will be discussed, focusing on its immunometabolic function as a metabokine, its secretion, its mechanism of action and possible roles in the cancer micro-environment. |Animals [MESH] |Humans [MESH] |Neoplasms/*enzymology/metabolism [MESH] |Nicotinamide Phosphoribosyltransferase/*metabolism [MESH]Extracellular nicotinamide phosphoribosyltransferase, a new cancer met(epmc).pdf DeepDyve Pubget Overpricing