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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Funct+Biomater
2012 ; 3
(3
): 569-87
Nephropedia Template TP
J Funct Biomater
2012[Aug]; 3
(3
): 569-87
PMID24955633
show ga
All vascular implants, including stents, heart valves and graft materials exhibit
suboptimal biocompatibility that significantly reduces their clinical efficacy. A
range of biomolecules in the subendothelial space have been shown to play
critical roles in local regulation of thrombosis, endothelial growth and smooth
muscle cell proliferation, making these attractive candidates for modulation of
vascular device biointegration. However, classically used biomaterial coatings,
such as fibronectin and laminin, modulate only one of these components; enhancing
endothelial cell attachment, but also activating platelets and triggering
thrombosis. This review examines a subset of extracellular matrix molecules that
have demonstrated multi-faceted vascular compatibility and accordingly are
promising candidates to improve the biointegration of vascular biomaterials.