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2016 ; 245
(3
): 351-60
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Extracellular matrix bioscaffolds in tissue remodeling and morphogenesis
#MMPMID26699796
Swinehart IT
; Badylak SF
Dev Dyn
2016[Mar]; 245
(3
): 351-60
PMID26699796
show ga
During normal morphogenesis the extracellular matrix (ECM) influences cell
motility, proliferation, apoptosis, and differentiation. Tissue engineers have
attempted to harness the cell signaling potential of ECM to promote the
functional reconstruction, if not regeneration, of injured or missing adult
tissues that otherwise heal by the formation of scar tissue. ECM bioscaffolds,
derived from decellularized tissues, have been used to promote the formation of
site appropriate, functional tissues in many clinical applications including
skeletal muscle, fibrocartilage, lower urinary tract, and esophageal
reconstruction, among others. These scaffolds function by the release or exposure
of growth factors and cryptic peptides, modulation of the immune response, and
recruitment of progenitor cells. Herein, we describe this process of ECM induced
constructive remodeling and examine similarities to normal tissue morphogenesis.