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2014 ; 15
(12
): 771-85
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Extracellular matrix assembly: a multiscale deconstruction
#MMPMID25370693
Mouw JK
; Ou G
; Weaver VM
Nat Rev Mol Cell Biol
2014[Dec]; 15
(12
): 771-85
PMID25370693
show ga
The biochemical and biophysical properties of the extracellular matrix (ECM)
dictate tissue-specific cell behaviour. The molecules that are associated with
the ECM of each tissue, including collagens, proteoglycans, laminins and
fibronectin, and the manner in which they are assembled determine the structure
and the organization of the resultant ECM. The product is a specific ECM
signature that is comprised of unique compositional and topographical features
that both reflect and facilitate the functional requirements of the tissue.