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2011 ; 71
(11
): 1006-17
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Extracellular matrix and the neural stem cell niche
#MMPMID21898854
Kazanis I
; ffrench-Constant C
Dev Neurobiol
2011[Nov]; 71
(11
): 1006-17
PMID21898854
show ga
Basal lamina is present in many stem cell niches, but we still have a poor
understanding of the role of this and other extracellular matrix (ECM)
components. Here, we review current knowledge regarding ECM expression and
function in the neural stem cell niche, focusing on the subependymal zone of the
adult CNS. An increasing complexity of ECM molecules has been described, and a
number of receptors expressed on the stem cells identified. Experiments
perturbing the niche using genetics or cytotoxic ablation of the rapidly dividing
precursors, or using explant culture models to examine specific growth factors,
have been influential in showing how changes in these ECM receptors might
regulate neural stem cell behavior. However the role of changes in the matrix
itself remains to be determined. The answers will be important, as they will
point to the molecules required to engineer niches ex-vivo so as to provide tools
for regenerative neuroscience.
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