Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1002/eji.201343866

http://scihub22266oqcxt.onion/10.1002/eji.201343866
suck pdf from google scholar
C4482763!4482763 !24448964
unlimited free pdf from europmc24448964
    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi


Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24448964 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117
pmid24448964
      Eur+J+Immunol 2014 ; 44 (4 ): 1119-29
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Extracellular adenosine controls NKT-cell-dependent hepatitis induction #MMPMID24448964
  • Subramanian M ; Kini R ; Madasu M ; Ohta A ; Nowak M ; Exley M ; Sitkovsky M ; Ohta A
  • Eur J Immunol 2014[Apr]; 44 (4 ): 1119-29 PMID24448964 show ga
  • Extracellular adenosine regulates inflammatory responses via the A2A adenosine receptor (A2AR). A2AR deficiency results in much exaggerated acute hepatitis, indicating nonredundancy of adenosine-A2AR pathway in inhibiting immune activation. To identify a critical target of immunoregulatory effect of extracellular adenosine, we focused on NKT cells, which play an indispensable role in hepatitis. An A2AR agonist abolished NKT-cell-dependent induction of acute hepatitis by concanavalin A (Con A) or ?-galactosylceramide in mice, corresponding to downregulation of activation markers and cytokines in NKT cells and of NK-cell co-activation. These results show that A2AR signaling can downregulate NKT-cell activation and suppress NKT-cell-triggered inflammatory responses. Next, we hypothesized that NKT cells might be under physiological control of the adenosine-A2AR pathway. Indeed, both Con A and ?-galactosylceramide induced more severe hepatitis in A2AR-deficient mice than in WT controls. Transfer of A2AR-deficient NKT cells into A2AR-expressing recipients resulted in exaggeration of Con A-induced liver damage, suggesting that NKT-cell activation is controlled by endogenous adenosine via A2AR, and this physiological regulatory mechanism of NKT cells is critical in the control of tissue-damaging inflammation. The current study suggests the possibility to manipulate NKT-cell activity in inflammatory disorders through intervention to the adenosine-A2AR pathway.
  • |Adenosine A2 Receptor Agonists/immunology/pharmacology [MESH]
  • |Adenosine A2 Receptor Antagonists/immunology/pharmacology [MESH]
  • |Adenosine/analogs & derivatives/*immunology/pharmacology [MESH]
  • |Animals [MESH]
  • |Cells, Cultured [MESH]
  • |Concanavalin A [MESH]
  • |Flow Cytometry [MESH]
  • |Galactosylceramides [MESH]
  • |Hepatitis, Animal/chemically induced/genetics/*immunology [MESH]
  • |Interferon-gamma/immunology/metabolism [MESH]
  • |Liver/immunology/metabolism/pathology [MESH]
  • |Mice [MESH]
  • |Mice, Inbred C57BL [MESH]
  • |Mice, Knockout [MESH]
  • |Natural Killer T-Cells/drug effects/*immunology/metabolism [MESH]
  • |Phenethylamines/immunology/pharmacology [MESH]
  • |Receptor, Adenosine A2A/*immunology/metabolism [MESH]
  • |Triazines/immunology/pharmacology [MESH]
  • |Triazoles/immunology/pharmacology [MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box