Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27979573
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27979573
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Trends+Cell+Biol
2017 ; 27
(3
): 172-188
Nephropedia Template TP
Trends Cell Biol
2017[Mar]; 27
(3
): 172-188
PMID27979573
show ga
Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound
carriers with complex cargoes including proteins, lipids, and nucleic acids.
While the release of EVs was previously thought to be only a mechanism to discard
nonfunctional cellular components, increasing evidence implicates EVs as key
players in intercellular and even interorganismal communication. EVs confer
stability and can direct their cargoes to specific cell types. EV cargoes also
appear to act in a combinatorial manner to communicate directives to other cells.
This review focuses on recent findings and knowledge gaps in the area of EV
biogenesis, release, and uptake. In addition, we highlight examples whereby EV
cargoes control basic cellular functions, including motility and polarization,
immune responses, and development, and contribute to diseases such as cancer and
neurodegeneration.