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2015 ; 22
(1
): 51-3
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Extra pontine osmotic demyelination syndrome
#MMPMID26124552
Zunga PM
; Farooq O
; Dar MI
; Dar IH
; Rashid S
; Rather AQ
; Basu JA
; Ashraf M
; Bhat JA
Ann Neurosci
2015[Jan]; 22
(1
): 51-3
PMID26124552
show ga
The osmotic demyelination syndrome (ODS) has been identified as a complication of
the rapid correction of hyponatremia for decades. However, in recent years, a
variety of other medical conditions have been associated with the development of
ODS, independent of changes in serum sodium which cause a rapid changes in
osmolality of the interstitial (extracellular) compartment of the brain leading
to dehydration of energy-depleted cells with subsequent axonal damage that occurs
in characteristic areas. Slow correction of the serum sodium concentration and
additional administration of corticosteroids seems to be a major prevention step
in ODS patients. In the current report we aimed to share a rare case which we
observed in our hospital. A 65 year old female admitted as altered sensorium with
history of vomiting, diarrhea was managed with intravenous fluids for 2 days at a
peripheral health centre. Patient was referred to our centre with encephalopathy,
evaluated and found to have hyponatremia and hypokalemia rest of biochemical
parameters and septic profile were normal. Patient's electrolyte disturbances
were managed as per guidelines but encephalopathy persisted. Supportive treatment
was continued and patient was discharged after 2 wks of stay in hospital after
gaining full sensorium and neurological functions.
free
free
free
