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2017 ; 151
(3
): 270-279
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Expression and trafficking of MR1
#MMPMID28419492
Lamichhane R
; Ussher JE
Immunology
2017[Jul]; 151
(3
): 270-279
PMID28419492
show ga
MHC class I-related gene protein (MR1) is a non-polymorphic MHC class IB
antigen-presenting molecule that is the restricting molecule for
mucosal-associated invariant T (MAIT) cells, a prominent population of
innate-like antibacterial T cells. The MAIT cell-MR1 axis represents a new
paradigm in antigen presentation, with the MR1 ligand derived from vitamin B
compounds or their metabolic precursors. Many bacteria and some fungi produce the
activating ligand for MR1. In evolution, MR1 is highly conserved in most, but not
all, mammals. In humans and rodents it is expressed in a broad range of cell
types, both haematopoietic and non-haematopoietic, although cell surface
expression has been difficult to detect. Although MR1 trafficking shares features
with both the MHC class I and MHC class II pathways, it is distinct. Several
strands of evidence suggest that the intracellular location where MR1 is loaded
differs for soluble ligand and for ligand derived from intact bacteria. The
regulation of MR1 surface expression may also vary between different cell types.
This paper will review what is currently known about the expression and
trafficking of MR1 and propose a model for the loading and trafficking of MR1.
|Amino Acid Sequence
[MESH]
|Animals
[MESH]
|Conserved Sequence
[MESH]
|Evolution, Molecular
[MESH]
|Gene Expression Regulation
[MESH]
|Histocompatibility Antigens Class I/genetics/immunology/*metabolism
[MESH]
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