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10.1194/jlr.R046656 http://scihub22266oqcxt.onion/10.1194/jlr.R046656 C4617347!4617347 !24474820     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24474820 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Lipid+Res 2014 ; 55 (9 ): 1839-46 Nephropedia Template TP {{tp|p=24474820 |t=2014. Export of sphingosine-1-phosphate and cancer progression |pdf=|usr=}}{{24474820 }} gab.com Text Export of sphingosine-1-phosphate and cancer progression JO: J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=24474820 #FOAvip Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator that promotes cell survival, proliferation, migration, angiogenesis, lymphangiogenesis, and immune response; all are critical processes of cancer progression. Although some important roles of intracellular S1P have recently been uncovered, the majority of its biological effects are known to be mediated via activation of five specific G protein-coupled receptors [S1P receptor (S1PR)1-S1PR5] located on the cell surface. Secretion of S1P produced inside cells by sphingosine kinases can then signal through these receptors in autocrine, paracrine, and/or endocrine manners, coined "inside-out" signaling of S1P. Numerous studies suggest that secreted S1P plays important roles in cancer progression; thus, understanding the mechanism by which S1P is exported out of cells, particularly cancer cells, is both interesting and important. Here we will review the current understanding of the transport of S1P out of cancer cells and its potential roles in the tumor microenvironment. Twit Text FOAVip Export of sphingosine-1-phosphate and cancer progression ????J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=24474820 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24474820 #FOAvip English Wikipedia <ref>{{Cite pmid|24474820 }}</ref> Export of sphingosine-1-phosphate and cancer progression #MMPMID24474820 Takabe K ; Spiegel S J Lipid Res 2014[Sep]; 55 (9 ): 1839-46 PMID24474820 show ga Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator that promotes cell survival, proliferation, migration, angiogenesis, lymphangiogenesis, and immune response; all are critical processes of cancer progression. Although some important roles of intracellular S1P have recently been uncovered, the majority of its biological effects are known to be mediated via activation of five specific G protein-coupled receptors [S1P receptor (S1PR)1-S1PR5] located on the cell surface. Secretion of S1P produced inside cells by sphingosine kinases can then signal through these receptors in autocrine, paracrine, and/or endocrine manners, coined "inside-out" signaling of S1P. Numerous studies suggest that secreted S1P plays important roles in cancer progression; thus, understanding the mechanism by which S1P is exported out of cells, particularly cancer cells, is both interesting and important. Here we will review the current understanding of the transport of S1P out of cancer cells and its potential roles in the tumor microenvironment. |Animals [MESH] |Biological Transport [MESH] |Disease Progression [MESH] |Humans [MESH] |Lymphangiogenesis [MESH] |Lysophospholipids/*metabolism [MESH] |Neoplasms/*metabolism [MESH] |Signal Transduction [MESH]Export of sphingosine-1-phosphate and cancer progression (epmc).pdf DeepDyve Pubget Overpricing