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2014 ; 369
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Exploring the evolutionary history of centrosomes
#MMPMID25047607
Azimzadeh J
Philos Trans R Soc Lond B Biol Sci
2014[Sep]; 369
(1650
): ä PMID25047607
show ga
The centrosome is the main organizer of the microtubule cytoskeleton in animals,
higher fungi and several other eukaryotic lineages. Centrosomes are usually
located at the centre of cell in tight association with the nuclear envelope and
duplicate at each cell cycle. Despite a great structural diversity between the
different types of centrosomes, they are functionally equivalent and share at
least some of their molecular components. In this paper, we explore the
evolutionary origin of the different centrosomes, in an attempt to understand
whether they are derived from an ancestral centrosome or evolved independently
from the motile apparatus of distinct flagellated ancestors. We then discuss the
evolution of centrosome structure and function within the animal lineage.