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2017 ; 5
(ä): e2990
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English Wikipedia
Exploring biomedical ontology mappings with graph theory methods
#MMPMID28265499
Kocbek S
; Kim JD
PeerJ
2017[]; 5
(ä): e2990
PMID28265499
show ga
BACKGROUND: In the era of semantic web, life science ontologies play an important
role in tasks such as annotating biological objects, linking relevant data
pieces, and verifying data consistency. Understanding ontology structures and
overlapping ontologies is essential for tasks such as ontology reuse and
development. We present an exploratory study where we examine structure and look
for patterns in BioPortal, a comprehensive publicly available repository of live
science ontologies. METHODS: We report an analysis of biomedical ontology mapping
data over time. We apply graph theory methods such as Modularity Analysis and
Betweenness Centrality to analyse data gathered at five different time points. We
identify communities, i.e., sets of overlapping ontologies, and define similar
and closest communities. We demonstrate evolution of identified communities over
time and identify core ontologies of the closest communities. We use BioPortal
project and category data to measure community coherence. We also validate
identified communities with their mutual mentions in scientific literature.
RESULTS: With comparing mapping data gathered at five different time points, we
identified similar and closest communities of overlapping ontologies, and
demonstrated evolution of communities over time. Results showed that anatomy and
health ontologies tend to form more isolated communities compared to other
categories. We also showed that communities contain all or the majority of
ontologies being used in narrower projects. In addition, we identified major
changes in mapping data after migration to BioPortal Version 4.