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10.1080/15384047.2017.1373220 http://scihub22266oqcxt.onion/10.1080/15384047.2017.1373220 C5678690!5678690 !28881163     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28881163 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28881163 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Biol+Ther 2017 ; 18 (10 ): 747-756 Nephropedia Template TP {{tp|p=28881163 |t=2017. Exploiting poly(I:C) to induce cancer cell apoptosis |pdf=|usr=}}{{28881163 }} gab.com Text Exploiting poly(I:C) to induce cancer cell apoptosis JO: Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=28881163 #FOAvip TLR3 belong to the Toll-like receptors family, it is mainly expressed on immune cells where it senses pathogen-associated molecular patterns and initiates innate immune response. TLR3 agonist poly(I:C) was developed to mimic pathogens infection and boost immune system activation to promote anti-cancer therapy. Accordingly, TLR agonists were included in the National Cancer Institute list of immunotherapeutic agents with the highest potential to cure cancer. Besides well known effects on immune cells, poly(I:C) was also shown, in experimental models, to directly induce apoptosis in cancer cells expressing TLR3. This review presents the current knowledge on the mechanism of poly(I:C)-induced apoptosis in cancer cells. Experimental evidences on positive or negative regulators of TLR3-mediated apoptosis induced by poly(I:C) are reported and strategies are proposed to successfully promote this event in cancer cells. Cancer cells apoptosis is an additional arm offered by poly(I:C), besides activation of immune system, for the treatment of various type of cancer. A further dissection of TLR3 signaling would contribute to greater resolution of the critical steps that impede full exploitation of the poly(I:C)-induced apoptosis. Experimental evidences about negative regulator of poly(I:C)-induced apoptotic program should be considered in combinations with TLR3 agonists in clinical trials. Twit Text FOAVip Exploiting poly(I:C) to induce cancer cell apoptosis ????Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=28881163 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28881163 #FOAvip English Wikipedia <ref>{{Cite pmid|28881163 }}</ref> Exploiting poly(I:C) to induce cancer cell apoptosis #MMPMID28881163 Bianchi F ; Pretto S ; Tagliabue E ; Balsari A ; Sfondrini L Cancer Biol Ther 2017[Oct]; 18 (10 ): 747-756 PMID28881163 show ga TLR3 belong to the Toll-like receptors family, it is mainly expressed on immune cells where it senses pathogen-associated molecular patterns and initiates innate immune response. TLR3 agonist poly(I:C) was developed to mimic pathogens infection and boost immune system activation to promote anti-cancer therapy. Accordingly, TLR agonists were included in the National Cancer Institute list of immunotherapeutic agents with the highest potential to cure cancer. Besides well known effects on immune cells, poly(I:C) was also shown, in experimental models, to directly induce apoptosis in cancer cells expressing TLR3. This review presents the current knowledge on the mechanism of poly(I:C)-induced apoptosis in cancer cells. Experimental evidences on positive or negative regulators of TLR3-mediated apoptosis induced by poly(I:C) are reported and strategies are proposed to successfully promote this event in cancer cells. Cancer cells apoptosis is an additional arm offered by poly(I:C), besides activation of immune system, for the treatment of various type of cancer. A further dissection of TLR3 signaling would contribute to greater resolution of the critical steps that impede full exploitation of the poly(I:C)-induced apoptosis. Experimental evidences about negative regulator of poly(I:C)-induced apoptotic program should be considered in combinations with TLR3 agonists in clinical trials. |Antineoplastic Agents/pharmacokinetics/*pharmacology/therapeutic use [MESH] |Apoptosis/*drug effects/immunology [MESH] |Cell Line, Tumor [MESH] |Humans [MESH] |Immunity, Innate/drug effects [MESH] |Neoplasms/immunology/mortality/pathology/*therapy [MESH] |Poly I-C/immunology/*pharmacology/therapeutic use [MESH] |Prognosis [MESH] |Signal Transduction/drug effects/immunology [MESH]Exploiting poly(I:C) to induce cancer cell apoptosis (epmc).pdf DeepDyve Pubget Overpricing