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2013 ; 5
(11
): a016980
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Exploiting endocytosis for nanomedicines
#MMPMID24186069
Akinc A
; Battaglia G
Cold Spring Harb Perspect Biol
2013[Nov]; 5
(11
): a016980
PMID24186069
show ga
In this article, we briefly review the endocytic pathways used by cells, pointing
out their defining characteristics and highlighting physical limitations that may
direct the internalization of nanoparticles to a subset of these pathways. A more
detailed description of these pathways is presented in the literature. We then
focus on the endocytosis of nanomedicines and present how various nanomaterial
parameters impact these endocytic processes. This topic is an area of active
research, motivated by the recognition that an improved understanding of how
nanomaterials interact at the molecular, cellular, and whole-organism level will
lead to the design of better nanomedicines in the future. Next, we briefly review
some of the important nanomedicines already on the market or in clinical
development that serve to exemplify how endocytosis can be exploited for medical
benefit. Finally, we present some key unanswered questions and remaining
challenges to be addressed by the field.