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2016 ; 5
(2
): 189-94
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Experimental models of renal calcium stones in rodents
#MMPMID26981444
Bilbault H
; Haymann JP
World J Nephrol
2016[Mar]; 5
(2
): 189-94
PMID26981444
show ga
In human nephrolithiasis, most stones are containing calcium and are located
within urinary cavities; they may contain monohydrate calcium oxalate, dihydrate
calcium oxalate and/or calcium phosphates in various proportion. Nephrolithiasis
may also be associated with nephrocalcinosis, i.e., crystal depositions in
tubular lumen and/or interstitium, an entity which suggests specific pathological
processes. Several rodents models have been developed in order to study the
pathophysiology of intrarenal crystal formation. We review here calcium rodent
models classified upon the presence of nephrolithiasis and/or nephrocalcinosis.
As rodents are not prone to nephrolithiasis, models require the induction of a
long standing hypercalciuria or hyperoxaluria (thus explaining the very few
studies reported), conversely to nephrocalcinosis which may occur within hours or
days. Whereas a nephrotoxicity leading to tubular injury and regeneration appears
as a critical event for crystal retention in nephrocalcinosis models,
surprisingly very little is known about the physiopathology of crystal attachment
to urothelium in nephrolithiasis. Creating new models of nephrolithiasis
especially in different genetic mice strains appears an important challenge in
order to unravel the early mechanisms of urinary stone formation in papilla and
fornices.