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2016 ; 90
(5
): 1025-1048
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Experimental models of liver fibrosis
#MMPMID26047667
Yanguas SC
; Cogliati B
; Willebrords J
; Maes M
; Colle I
; van den Bossche B
; de Oliveira CPMS
; Andraus W
; Alves VAF
; Leclercq I
; Vinken M
Arch Toxicol
2016[May]; 90
(5
): 1025-1048
PMID26047667
show ga
Hepatic fibrosis is a wound healing response to insults and as such affects the
entire world population. In industrialized countries, the main causes of liver
fibrosis include alcohol abuse, chronic hepatitis virus infection and
non-alcoholic steatohepatitis. A central event in liver fibrosis is the
activation of hepatic stellate cells, which is triggered by a plethora of
signaling pathways. Liver fibrosis can progress into more severe stages, known as
cirrhosis, when liver acini are substituted by nodules, and further to
hepatocellular carcinoma. Considerable efforts are currently devoted to liver
fibrosis research, not only with the goal of further elucidating the molecular
mechanisms that drive this disease, but equally in view of establishing effective
diagnostic and therapeutic strategies. The present paper provides a
state-of-the-art overview of in vivo and in vitro models used in the field of
experimental liver fibrosis research.
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