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2017 ; 15
(1
): 157-165
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Exosomes: The Messengers of Health and Disease
#MMPMID27568544
Isola AL
; Chen S
Curr Neuropharmacol
2017[]; 15
(1
): 157-165
PMID27568544
show ga
Exosomes are small vesicles comprised of a lipid bilayer containing various
proteins, RNAs and bioactive lipids. They act as intercellular messengers that
give the ability to communicate between both cells of the same type and other
cell types. They are released by healthy cells, both constitutively and upon cell
activation and play an important role in immune system function. Exosomes are
essential for healthy physiological conditions, however under pathological
circumstances, they act to potentiate cellular stress and damage. This review
explores the characteristics, biogenesis, role(s) in the pathogenesis of diseases
and role(s) in progression of cancer of these nano-sized messages-in-a-vesicle:
exosomes.