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2015 ; 4
(ä): 7
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Exosomes: Mechanisms of Uptake
#MMPMID28936243
McKelvey KJ
; Powell KL
; Ashton AW
; Morris JM
; McCracken SA
J Circ Biomark
2015[Jan]; 4
(ä): 7
PMID28936243
show ga
Exosomes are 30-100 nm microvesicles which contain complex cellular signals of
RNA, protein and lipids. Because of this, exosomes are implicated as having
limitless therapeutic potential for the treatment of cancer, pregnancy
complications, infections, and autoimmune diseases. To date we know a
considerable amount about exosome biogenesis and secretion, but there is a
paucity of data regarding the uptake of exosomes by immune and non-immune cell
types (e.g., cancer cells) and the internal signalling pathways by which these
exosomes elicit a cellular response. Answering these questions is of paramount
importance.