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2017 ; 72
(4
): 534-544
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Exosomes in immunoregulation of chronic lung diseases
#MMPMID27859351
Hough KP
; Chanda D
; Duncan SR
; Thannickal VJ
; Deshane JS
Allergy
2017[Apr]; 72
(4
): 534-544
PMID27859351
show ga
Exosomes are nano-sized, membrane-bound vesicles released from cells that
transport cargo including DNA, RNA, and proteins, between cells as a form of
intercellular communication. In addition to their role in intercellular
communication, exosomes are beginning to be appreciated as agents of
immunoregulation that can modulate antigen presentation, immune activation,
suppression, and surveillance. This article summarizes how these multifaceted
functions of exosomes may promote development and/or progression of chronic
inflammatory lung diseases including asthma, chronic obstructive pulmonary
disease, and pulmonary fibrosis. The potential of exosomes as a novel therapeutic
is also discussed.