Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26089917
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Stem+Cells+Int
2015 ; 2015
(ä): 482171
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Exosomes for Intramyocardial Intercellular Communication
#MMPMID26089917
Cervio E
; Barile L
; Moccetti T
; Vassalli G
Stem Cells Int
2015[]; 2015
(ä): 482171
PMID26089917
show ga
Cross-talk between different cell types plays central roles both in cardiac
homeostasis and in adaptive responses of the heart to stress. Cardiomyocytes
(CMs) send biological messages to the other cell types present in the heart
including endothelial cells (ECs) and fibroblasts. In turn, CMs receive messages
from these cells. Recent evidence has now established that exosomes, nanosized
secreted extracellular vesicles, are crucial mediators of such messages. CMs,
ECs, cardiac fibroblasts, and cardiac progenitor cells (CPCs) release exosomes
carrying nonrandom subsets of proteins, lipids, and nucleic acids present in
their cells of origin. Exosomes secreted from CMs are internalized by fibroblasts
and regulate gene expression in these cells as well as in ECs. CPC-derived
exosomes protect CMs against apoptosis while also stimulating angiogenesis. They
are rich in cardioprotective and proangiogenic microRNAs such as miR-146,
miR-210, and miR-132. When injected into infracted hearts in vivo, CPC-derived
exosomes reduce infarct size and improve cardiac function. Thus, exosomes are
emerging both as key mediators of intercellular communication in the heart and as
therapeutic candidates for heart disease.
free
free
free
