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2016 ; 13
(2
): 113-6
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Exosomes Mediate the Intercellular Communication after Myocardial Infarction
#MMPMID26941569
Yuan MJ
; Maghsoudi T
; Wang T
Int J Med Sci
2016[]; 13
(2
): 113-6
PMID26941569
show ga
The mechanisms of cardiac repair after myocardial infarction (MI) are complicated
and not well-understood currently. It is known that exosomes are released from
most cells, recognized as new candidates with important roles in intercellular
and tissue-level communication. Cells can package proteins and RNA messages into
exosome and secret to recipient cells, which regulate gene expression in
recipient cells. The research on exosomes in cardiovascular disease is just
emerging. It is well-known that exosomes from cardiomyocyte can transfect
endothelial cells, stem cells, fibroblasts and smooth muscle cells to induce
cellular changes. After myocardial infarction (MI), the exosomes play important
roles in local and distant microcommunication. Nowadays, exosomal microRNAs
transportation has been found to deliver signals to mediate cardiac repair after
MI. However, the exosomes quality and quantities are variable under different
pathological conditions. Therefore, we speculate that the monitoring of the
quality and quantity of exosomes may serve as diagnosis and prognosis biomarkers
of MI, and the study of exosomes will provide insights for the new therapeutics
to cardiac remodeling after MI.