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10.1093/bioinformatics/btt171

http://scihub22266oqcxt.onion/10.1093/bioinformatics/btt171
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suck abstract from ncbi


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pmid23589649
      Bioinformatics 2013 ; 29 (12 ): 1565-7
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  • Exome-based analysis for RNA epigenome sequencing data #MMPMID23589649
  • Meng J ; Cui X ; Rao MK ; Chen Y ; Huang Y
  • Bioinformatics 2013[Jun]; 29 (12 ): 1565-7 PMID23589649 show ga
  • MOTIVATION: Fragmented RNA immunoprecipitation combined with RNA sequencing enabled the unbiased study of RNA epigenome at a near single-base resolution; however, unique features of this new type of data call for novel computational techniques. RESULT: Through examining the connections of RNA epigenome sequencing data with two well-studied data types, ChIP-Seq and RNA-Seq, we unveiled the salient characteristics of this new data type. The computational strategies were discussed accordingly, and a novel data processing pipeline was proposed that combines several existing tools with a newly developed exome-based approach 'exomePeak' for detecting, representing and visualizing the post-transcriptional RNA modification sites on the transcriptome. AVAILABILITY: The MATLAB package 'exomePeak' and additional details are available at http://compgenomics.utsa.edu/exomePeak/.
  • |*Epigenesis, Genetic [MESH]
  • |*Exome [MESH]
  • |*RNA Processing, Post-Transcriptional [MESH]
  • |HEK293 Cells [MESH]
  • |Humans [MESH]
  • |Immunoprecipitation/methods [MESH]
  • |Sequence Analysis, RNA/*methods [MESH]
  • |Software [MESH]


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