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2015 ; 60
(6
): 537-43
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Exogenous Ochronosis
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Bhattar PA
; Zawar VP
; Godse KV
; Patil SP
; Nadkarni NJ
; Gautam MM
Indian J Dermatol
2015[Nov]; 60
(6
): 537-43
PMID26677264
show ga
Exogenous ochronosis (EO) is a cutaneous disorder characterized by blue-black
pigmentation resulting as a complication of long-term application of
skin-lightening creams containing hydroquinone but may also occur due to topical
contact with phenol or resorcinol in dark-skinned individuals. It can also occur
following the use of systemic antimalarials such as quinine. EO is clinically and
histologically similar to its endogenous counterpart viz., alkaptonuria, which,
however, exhibits systemic effects and is an inherited disorder. Dermoscopy and
in vivo skin reflectance confocal microscopy are noninvasive in vivo diagnostic
tools. It is very difficult to treat EO, a cosmetically disfiguring and troubling
disorder with disappointing treatment options.