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10.1371/journal.pbio.1002321 http://scihub22266oqcxt.onion/10.1371/journal.pbio.1002321 C4671562!4671562 !26641938     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26641938 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+Biol 2015 ; 13 (12 ): e1002321 Nephropedia Template TP {{tp|p=26641938 |t=2015. Exceptional Antibodies Produced by Successive Immunizations |pdf=|usr=}}{{26641938 }} gab.com Text Exceptional Antibodies Produced by Successive Immunizations JO: PLoS Biol http://www.kidney.de/pget.php?&tw=1&pmid=26641938 #FOAvip Antibodies stand between us and pathogens. Viruses mutate quickly to avoid detection, and antibodies mutate at similar rates to hunt them down. This death spiral is fueled by specialized proteins and error-prone polymerases that change DNA sequences. Here, we explore how B lymphocytes stay in the race by expressing activation-induced deaminase, which unleashes a tsunami of mutations in the immunoglobulin loci. This produces random DNA substitutions, followed by selection for the highest affinity antibodies. We may be able to manipulate the process to produce better antibodies by expanding the repertoire of specific B cells through successive vaccinations. Twit Text FOAVip Exceptional Antibodies Produced by Successive Immunizations ????PLoS Biol http://www.kidney.de/pget.php?&tw=1&pmid=26641938 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26641938 #FOAvip English Wikipedia <ref>{{Cite pmid|26641938 }}</ref> Exceptional Antibodies Produced by Successive Immunizations #MMPMID26641938 Gearhart PJ ; Castiblanco DP ; Russell Knode LM PLoS Biol 2015[Dec]; 13 (12 ): e1002321 PMID26641938 show ga Antibodies stand between us and pathogens. Viruses mutate quickly to avoid detection, and antibodies mutate at similar rates to hunt them down. This death spiral is fueled by specialized proteins and error-prone polymerases that change DNA sequences. Here, we explore how B lymphocytes stay in the race by expressing activation-induced deaminase, which unleashes a tsunami of mutations in the immunoglobulin loci. This produces random DNA substitutions, followed by selection for the highest affinity antibodies. We may be able to manipulate the process to produce better antibodies by expanding the repertoire of specific B cells through successive vaccinations. |*Immunity, Active [MESH] |*Immunization, Secondary [MESH] |*Immunologic Memory [MESH] |*Models, Immunological [MESH] |AICDA (Activation-Induced Cytidine Deaminase) [MESH] |Animals [MESH] |Antibodies, Viral/analysis/*biosynthesis/genetics [MESH] |Antibody Affinity [MESH] |Antigens, Viral/adverse effects/therapeutic use [MESH] |B-Lymphocytes/*immunology/metabolism [MESH] |Cytidine Deaminase/metabolism [MESH] |Humans [MESH] |Mutation [MESH]Exceptional Antibodies Produced by Successive Immunizations (epmc).pdf DeepDyve Pubget Overpricing