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Evolving spectrum of HIV-associated rheumatic syndromes
#MMPMID26362742
Fox C
; Walker-Bone K
Best Pract Res Clin Rheumatol
2015[Apr]; 29
(2
): 244-58
PMID26362742
show ga
At the end of 2013, 35 million people worldwide were infected with HIV. The
prognosis of HIV has been transformed by combination antiretroviral therapy
(cART). Providing compliance is good, the use of cART has normalised the life
expectancy of HIV-infected people leading to a growing population of people with
chronic infection. Management of HIV patients has therefore needed to adapt in
order to not only control viral activity but also manage long-term complications
of HIV and cART. Rheumatological manifestations of HIV were first described in
1989. Since then, there have been case reports, case series and epidemiological
studies describing different clinical manifestations of HIV in the
musculoskeletal system. This review will encompass musculoskeletal pain,
fibromyalgia, systemic lupus erythematosus (SLE) and inflammatory arthritis in
HIV. We will aim to report on the prevalence of these conditions and the risk
factors, explore the impact of the virus on the clinical presentations and
discuss implications for diagnosis and management.