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2015 ; 61 Suppl 2
(Suppl 2
): S48-57
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Evolving resistance among Gram-positive pathogens
#MMPMID26316558
Munita JM
; Bayer AS
; Arias CA
Clin Infect Dis
2015[Sep]; 61 Suppl 2
(Suppl 2
): S48-57
PMID26316558
show ga
Antimicrobial therapy is a key component of modern medical practice and a
cornerstone for the development of complex clinical interventions in critically
ill patients. Unfortunately, the increasing problem of antimicrobial resistance
is now recognized as a major public health threat jeopardizing the care of
thousands of patients worldwide. Gram-positive pathogens exhibit an immense
genetic repertoire to adapt and develop resistance to virtually all
antimicrobials clinically available. As more molecules become available to treat
resistant gram-positive infections, resistance emerges as an evolutionary
response. Thus, antimicrobial resistance has to be envisaged as an evolving
phenomenon that demands constant surveillance and continuous efforts to identify
emerging mechanisms of resistance to optimize the use of antibiotics and create
strategies to circumvent this problem. Here, we will provide a broad perspective
on the clinical aspects of antibiotic resistance in relevant gram-positive
pathogens with emphasis on the mechanistic strategies used by these organisms to
avoid being killed by commonly used antimicrobial agents.
|Animals
[MESH]
|Anti-Bacterial Agents/*pharmacology/therapeutic use
[MESH]
free
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