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10.1093/gbe/evw025 http://scihub22266oqcxt.onion/10.1093/gbe/evw025 C4824033!4824033 !26966239     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26966239 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genome+Biol+Evol 2016 ; 8 (3 ): 562-77 Nephropedia Template TP {{tp|p=26966239 |t=2016. Evolutionary Insights into RNA trans-Splicing in Vertebrates |pdf=|usr=}}{{26966239 }} gab.com Text Evolutionary Insights into RNA trans-Splicing in Vertebrates JO: Genome Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=26966239 #FOAvip Pre-RNA splicing is an essential step in generating mature mRNA. RNA trans-splicing combines two separate pre-mRNA molecules to form a chimeric non-co-linear RNA, which may exert a function distinct from its original molecules. Trans-spliced RNAs may encode novel proteins or serve as noncoding or regulatory RNAs. These novel RNAs not only increase the complexity of the proteome but also provide new regulatory mechanisms for gene expression. An increasing amount of evidence indicates that trans-splicing occurs frequently in both physiological and pathological processes. In addition, mRNA reprogramming based on trans-splicing has been successfully applied in RNA-based therapies for human genetic diseases. Nevertheless, clarifying the extent and evolution of trans-splicing in vertebrates and developing detection methods for trans-splicing remain challenging. In this review, we summarize previous research, highlight recent advances in trans-splicing, and discuss possible splicing mechanisms and functions from an evolutionary viewpoint. Twit Text FOAVip Evolutionary Insights into RNA trans-Splicing in Vertebrates ????Genome Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=26966239 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26966239 #FOAvip English Wikipedia <ref>{{Cite pmid|26966239 }}</ref> Evolutionary Insights into RNA trans-Splicing in Vertebrates #MMPMID26966239 Lei Q ; Li C ; Zuo Z ; Huang C ; Cheng H ; Zhou R Genome Biol Evol 2016[Mar]; 8 (3 ): 562-77 PMID26966239 show ga Pre-RNA splicing is an essential step in generating mature mRNA. RNA trans-splicing combines two separate pre-mRNA molecules to form a chimeric non-co-linear RNA, which may exert a function distinct from its original molecules. Trans-spliced RNAs may encode novel proteins or serve as noncoding or regulatory RNAs. These novel RNAs not only increase the complexity of the proteome but also provide new regulatory mechanisms for gene expression. An increasing amount of evidence indicates that trans-splicing occurs frequently in both physiological and pathological processes. In addition, mRNA reprogramming based on trans-splicing has been successfully applied in RNA-based therapies for human genetic diseases. Nevertheless, clarifying the extent and evolution of trans-splicing in vertebrates and developing detection methods for trans-splicing remain challenging. In this review, we summarize previous research, highlight recent advances in trans-splicing, and discuss possible splicing mechanisms and functions from an evolutionary viewpoint. |*Evolution, Molecular [MESH] |*Genetic Diseases, Inborn [MESH] |Animals [MESH] |Cellular Reprogramming/genetics [MESH] |Humans [MESH] |RNA Precursors/*genetics [MESH] |RNA Splicing [MESH] |Trans-Splicing/*genetics [MESH]Evolutionary Insights into RNA trans-Splicing in Vertebrates (epmc).pdf DeepDyve Pubget Overpricing