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2014 ; 71
(24
): 4763-80
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Evolution of nonclassical MHC-dependent invariant T cells
#MMPMID25117267
Edholm ES
; Grayfer L
; Robert J
Cell Mol Life Sci
2014[Dec]; 71
(24
): 4763-80
PMID25117267
show ga
TCR-mediated specific recognition of antigenic peptides in the context of
classical MHC molecules is a cornerstone of adaptive immunity of jawed
vertebrate. Ancillary to these interactions, the T cell repertoire also includes
unconventional T cells that recognize endogenous and/or exogenous antigens in a
classical MHC-unrestricted manner. Among these, the mammalian nonclassical MHC
class I-restricted invariant T cell (iT) subsets, such as iNKT and MAIT cells,
are now believed to be integral to immune response initiation as well as in
orchestrating subsequent adaptive immunity. Until recently the evolutionary
origins of these cells were unknown. Here we review our current understanding of
a nonclassical MHC class I-restricted iT cell population in the amphibian Xenopus
laevis. Parallels with the mammalian iNKT and MAIT cells underline the crucial
biological roles of these evolutionarily ancient immune subsets.
|*Biological Evolution
[MESH]
|Adaptive Immunity/immunology
[MESH]
|Animals
[MESH]
|Antigen Presentation/immunology
[MESH]
|Histocompatibility Antigens Class I/*immunology
[MESH]
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