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10.1016/j.cub.2012.07.008 http://scihub22266oqcxt.onion/10.1016/j.cub.2012.07.008 C4662249!4662249 !22975006     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22975006 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Curr+Biol 2012 ; 22 (17 ): R753-61 Nephropedia Template TP {{tp|p=22975006 |t=2012. Evolution of neurodegeneration |pdf=|usr=}}{{22975006 }} gab.com Text Evolution of neurodegeneration JO: Curr Biol http://www.kidney.de/pget.php?&tw=1&pmid=22975006 #FOAvip A number of neurodegenerative diseases principally affect humans as they age and are characterized by the loss of specific groups of neurons in different brain regions. Although these disorders are generally sporadic, it is now clear that many of them have a substantial genetic component. As genes are the raw material with which evolution works, we might benefit from understanding these genes in an evolutionary framework. Here, I will discuss how we can understand whether evolution has shaped genes involved in neurodegeneration and the implications for practical issues, such as our choice of model systems for studying these diseases, and more theoretical concerns, such as the level of selection against these phenotypes. Twit Text FOAVip Evolution of neurodegeneration ????Curr Biol http://www.kidney.de/pget.php?&tw=1&pmid=22975006 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22975006 #FOAvip English Wikipedia <ref>{{Cite pmid|22975006 }}</ref> Evolution of neurodegeneration #MMPMID22975006 Cookson MR Curr Biol 2012[Sep]; 22 (17 ): R753-61 PMID22975006 show ga A number of neurodegenerative diseases principally affect humans as they age and are characterized by the loss of specific groups of neurons in different brain regions. Although these disorders are generally sporadic, it is now clear that many of them have a substantial genetic component. As genes are the raw material with which evolution works, we might benefit from understanding these genes in an evolutionary framework. Here, I will discuss how we can understand whether evolution has shaped genes involved in neurodegeneration and the implications for practical issues, such as our choice of model systems for studying these diseases, and more theoretical concerns, such as the level of selection against these phenotypes. |*Biological Evolution [MESH] |Dementia/epidemiology/genetics/pathology [MESH] |Humans [MESH] |Neurodegenerative Diseases/*epidemiology/genetics/pathology [MESH]Evolution of neurodegeneration (epmc).pdf DeepDyve Pubget Overpricing