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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Mol+Evol
2015 ; 80
(5-6
): 251-7
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Evolution of Enzyme Kinetic Mechanisms
#MMPMID25987355
Ulusu NN
J Mol Evol
2015[Jun]; 80
(5-6
): 251-7
PMID25987355
show ga
This review paper discusses the reciprocal kinetic behaviours of enzymes and the
evolution of structure-function dichotomy. Kinetic mechanisms have evolved in
response to alterations in ecological and metabolic conditions. The kinetic
mechanisms of single-substrate mono-substrate enzyme reactions are easier to
understand and much simpler than those of bi-bi substrate enzyme reactions. The
increasing complexities of kinetic mechanisms, as well as the increasing number
of enzyme subunits, can be used to shed light on the evolution of kinetic
mechanisms. Enzymes with heterogeneous kinetic mechanisms attempt to achieve
specific products to subsist. In many organisms, kinetic mechanisms have evolved
to aid survival in response to changing environmental factors. Enzyme promiscuity
is defined as adaptation to changing environmental conditions, such as the
introduction of a toxin or a new carbon source. Enzyme promiscuity is defined as
adaptation to changing environmental conditions, such as the introduction of a
toxin or a new carbon source. Enzymes with broad substrate specificity and
promiscuous properties are believed to be more evolved than single-substrate
enzymes. This group of enzymes can adapt to changing environmental substrate
conditions and adjust catalysing mechanisms according to the substrate's
properties, and their kinetic mechanisms have evolved in response to substrate
variability.
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